Lung and myocardial thallium-201 kinetics in resting patients with congestive heart failure: Correlation with pulmonary capillary wedge pressure
| Autor: | Roberto Roberti, Steven F. Horowitz, Dirceu R. Almeida, Eulogio E. Martinez, Manoel A. Saragoça, Mario L.V. Castiglioni, Antonio Carlos Camargo de Carvalho, Hélio José Castello, Antonio Barbieri |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Increased pulmonary capillary wedge pressure medicine.medical_specialty Time Factors Heart disease Rest Cardiomyopathy chemistry.chemical_element Hemodynamics Ventricular Function Left Internal medicine medicine Humans Pulmonary Wedge Pressure cardiovascular diseases Radionuclide Imaging Pulmonary wedge pressure Lung Heart Failure business.industry Heart Middle Aged medicine.disease Thallium Radioisotopes medicine.anatomical_structure chemistry Catheterization Swan-Ganz Heart failure cardiovascular system Cardiology Thallium Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | American Heart Journal. 123:427-432 |
| ISSN: | 0002-8703 |
| DOI: | 10.1016/0002-8703(92)90657-h |
| Popis: | Increased lung thallium-201 activity occurs with exercise in patients with severe coronary artery disease as a result of increased pulmonary capillary wedge pressure. No study has shown resting lung kinetics in chronic congestive heart failure. To better understand the relationship between lung and myocardial thallium uptake and pulmonary capillary wedge pressure, this study was performed. Resting lung and myocardial thallium uptake, expressed as a ratio, were compared with simultaneous pulmonary capillary wedge pressure in 16 patients with congestive heart failure and cardiomyopathy, all New York Heart Association class IV. There were no variations in pulmonary capillary wedge pressure throughout the study protocol. There was a significant reduction in the lung/myocardium thallium ratio from 10 to 60 minutes (0.83 +/- 0.30 to 0.59 +/- 0.17; p less than 0.001). At 60 minutes after thallium injection there was a linear correlation between the lung/myocardium ratio and capillary wedge pressure with an r value of 0.62 (p less than 0.01). Thus thallium-201 washout is rapid despite persistence of pulmonary capillary wedge pressure elevation, indicating that clearance does not imply resolution of congestive heart failure. In addition, a significant but imprecise correlation was found between capillary pressure and the lung/myocardium ratio. Rapid changes in lung activity during the early postinjection period may limit the clinical use of the lung/myocardium ratio. |
| Databáze: | OpenAIRE |
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