Two new 8-isopentenyl isoflavane derivatives from Astragalus dolichochaete diels
| Autor: | Lin Qiu, Xin-Yan Tian, Ding-Wei Wang, Bei Jiang, Chao-Jiang Xiao, Dong Xiang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Traditional medicine
biology 010405 organic chemistry Organic Chemistry Ethyl acetate Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Hepatoma cell line chemistry.chemical_compound Astragalus chemistry Cell culture Radix Human gastric carcinoma Cytotoxicity Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Natural Product Research. 35:1323-1330 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2019.1647426 |
| Popis: | Astragali Radix (Huangqi) is one of the well-known traditional Chinese medicines and has been used in China for more than two thousand years. As a close species, Astragalus dolichochaete Diels was found to possess cytotoxicity during our preliminary study of Astragalus plants from Yunnan Province, China. To better understand the chemical foundation of the cytotoxicity, the major constituents of A. dolichochaete were studied. As a result, two new 8-isopentenyl isoflavane derivatives, dolichochaeteins A and B (1 and 2), together with ten known constituents were isolated, and their structures were elucidated by means of spectroscopy, mainly 1D and 2D NMR techniques. The cytotoxic activities were evaluated for the raw extract, ethyl acetate fraction, compound 2 and glyasperin H (3) against human gastric carcinoma cell line SGC-7901, human hepatoma cell line SMMC-7721 and human leukemic cell line K562. All the samples exhibited significant cytotoxicity. |
| Databáze: | OpenAIRE |
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