Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

Autor: Vicente Vila-Bou, Silvia M. Sanz-González, J. Fernando Arevalo, Antonio Lleó-Pérez, Bárbara Vivar-Llopis, Jose Javier Garcia-Medina, Carla Marco-Ramírez, Mara Albert-Fort, E. Bendala-Tufanisco, Maria D Pinazo-Duran, Vicente Zanon-Moreno, María I. López-Gálvez, María F. García-Esparza, Rosa Dolz-Marco, Luis Alonso-Muñoz, C. Galbis-Estrada, Kian Shoaie-Nia, Roberto Gallego-Pinazo, Carlo Nucci, María J. Roig-Revert, David Galarreta-Mira, Juan Marín-Montiel
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Blood Glucose
Male
optical coherence
Glycated Hemoglobin A
lcsh:Medicine
Type 2 diabetes
medicine.disease_cause
Gastroenterology
Antioxidants
chemistry.chemical_compound
Malondialdehyde
80 and over
glycosylated
Aged
80 and over
education.field_of_study
General Medicine
Diabetic retinopathy
Middle Aged
type 2
diabetes mellitus
Female
omega-3
Tomography
Optical Coherence
Research Article
Retinopathy
Adult
medicine.medical_specialty
Article Subject
hemoglobin A
Population
tomography
fatty acids
General Biochemistry
Genetics and Molecular Biology
Internal medicine
Fatty Acids
Omega-3
medicine
Humans
education
Triglycerides
Aged
Glycated Hemoglobin
Diabetic Retinopathy
General Immunology and Microbiology
Settore MED/30 - Malattie Apparato Visivo
business.industry
adult
aged
aged
80 and over
antioxidants
biomarkers
blood glucose
diabetes mellitus
type 2
diabetic retinopathy
fatty acids
omega-3
female
hemoglobin A
glycosylated
humans
male
malondialdehyde
middle aged
oxidative stress
tomography
optical coherence
triglycerides
dietary supplements
lcsh:R
Type 2 Diabetes Mellitus
medicine.disease
Oxidative Stress
Endocrinology
Diabetes Mellitus
Type 2
chemistry
Dietary Supplements
Hemoglobin
business
Biomarkers
Oxidative stress
Zdroj: BioMed Research International, Vol 2015 (2015)
BIOMED RESEARCH INTERNATIONAL
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
BioMed Research International
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
BioMed research international
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
ISSN: 2314-6141
2314-6133
Popis: We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants were distributed into two main groups: (1) T2DMG (with retinopathy (+DR) or without retinopathy (−DR)) and (2) controls (CG). Participants were randomly assigned (+A/ω3) or not (−A/ω3) to the oral supplementation with a daily pill of Nutrof Omega (R) for 18 months. Data collected including demographics, anthropometrics, characteristics/lifestyle, ophthalmic examination (best corrected visual acuity, ocular fundus photographs, and retinal thickness as assessed by optical coherence tomography), and blood parameters (glucose, glycosylated hemoglobin, triglycerides, malondialdehyde, and total antioxidant capacity) were registered, integrated, and statistically processed by the SPSS 15.0 program. Finally, 208 participants (130 diabetics (68 +DR/62 −DR) and 78 controls) completed the follow-up. Blood analyses confirmed that the T2DMG+DR patients had significantly higher oxidative stress(p<0.05), inflammatory(p<0.05), and vascular(p<0.001)risk markers than the T2DMG−DR and the CG. Furthermore, the A/ω3 oral supplementation positively changed the baseline parameters, presumptively by inducing metabolic activation and ameliorating the ocular health after 18 months of supplementation.
Databáze: OpenAIRE
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