Age-dependent decreases in serum soluble interleukin-1 receptor type I (sIL-1RI) in healthy individuals: a population study of serum sIL-1RI levels in Japanese subjects
| Autor: | Mayuri Tanaka, Takashi Fukui, Nobuhiro Miyahara, Naoya Fujita, Mie Tanabe, Takuhito Nagai, Yoshihiro Okamoto, Toshiyuki Masuzawa, Yoshimitsu Gotoh |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Microbiology (medical) Aging medicine.medical_specialty Adolescent medicine.medical_treatment Clinical Biochemistry Age dependent Soluble Interleukin-1 Receptor Type I Receptor type Young Adult Japan Internal medicine medicine Humans Immunology and Allergy Child Receptor Aged Receptors Interleukin-1 Type I Sex Characteristics business.industry Biochemistry (medical) Public Health Environmental and Occupational Health Healthy subjects Infant Original Articles Hematology Middle Aged Medical Laboratory Technology Endocrinology Cytokine Health Child Preschool Data Interpretation Statistical Healthy individuals Population study Female business |
| Zdroj: | Journal of Clinical Laboratory Analysis. 23:175-178 |
| ISSN: | 1098-2825 0887-8013 |
| DOI: | 10.1002/jcla.20315 |
| Popis: | The levels of several soluble cytokine receptors in body fluids of healthy individuals change with age. Clinical application of the measurement of the serum soluble interleukin‐1 receptor type I (sIL‐1RI) level depends critically on the samples used as the controls. At present, there is no information regarding the levels of serum sIL‐1RI in healthy subjects. The purpose of this study is to reveal the age‐related changes that occur in the serum sIL‐1RIlevels of healthy individuals. We determined the serum sIL‐1RI levels of healthy Japanese children using ELISA. The serum sIL‐1RI level of children (0–14 years) was significantly higher than that of adults (more than 15 years) (P=0.0138, n=90). Thus, it is recommended that when the serum sIL‐1RI level of patients is evaluated, it should be compared against age‐matched controls. J. Clin. Lab. Anal. 23:175–178, 2009. © 2009 Wiley‐Liss, Inc. |
| Databáze: | OpenAIRE |
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