Evaluation of energy sources with and without carnitine in newborn pig heart and liver
| Autor: | Dale C. Honeyfield, John A. Froseth |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Vitamin
medicine.medical_specialty Swine animal diseases Lysine Medicine (miscellaneous) Biology Substrate Specificity chemistry.chemical_compound Oxygen Consumption Pregnancy Internal medicine Carnitine medicine Animals Maternal-Fetal Exchange Isovalerate Nutrition and Dietetics Heart Metabolism Metabolic intermediate Dietary Fats Mitochondria Endocrinology chemistry Animals Newborn Liver Gestation Female Energy source Energy Metabolism medicine.drug |
| Zdroj: | The Journal of nutrition. 121(7) |
| ISSN: | 0022-3166 |
| Popis: | The oxidation rate of five energy sub strates with and without exogenous addition of carnit- ine in the heart and liver of 15-h-old nonsuckled piglets was evaluated. Oxygen consumption (nmol A›2mg protein"1min"1) in heart and liver for five substrates were: pyruvate, 0.248, 0.191; palmitoyl-CoA, 0.042, 0.034; palmitoyl-carnitine, 0.249, 0.111; isovalerate, 0.084, 0.059; acetoacetate, 0.166, 0.068, respec tively. The addition of free carnitine doubled the rate of palmitoyl-CoA utilization in both heart and liver, but palmitoyl-CoA oxidation was always much lower than that of palmitoyl-carnitine. In livers of piglets from sows fed 8% fat, palmitoyl-carnitine oxidation was slower (P < 0.03) than in piglets from sows fed 0% fat. Heart tissue metabolized isovalerate faster (P < 0.02) when piglets were from sows fed fat compared with those from the nonfat group. A lysine x fat interaction was observed for piglet liver metabolism of isovalerate and acetoacetate, suggesting that a more metaboli- cally developed pig results when sows are fed 0.48% lysine without supplemental fat during gestation. Car nitine did not seem to be the limiting factor for the oxidation of palmitoyl-CoA, and gestational dietary fat and lysine seemed to influence substrate metabolism in the newborn pig. J. Nutr. 121: 1117-1122, 1991. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|