Measurement of erythrocyte creatine might be useful for diagnosing latent hemolysis

Autor: Hiroko Ijima, Kazuyuki Hiratani, Hideaki Jinnnouchi, Yasuhiro Ono, Masashi Kameyama, Toshika Okumiya, Masafumi Koga
Rok vydání: 2022
Předmět:
Zdroj: Clinical Biochemistry. 107:50-54
ISSN: 0009-9120
DOI: 10.1016/j.clinbiochem.2022.05.007
Popis: Whereas HbA1c values are low relative to glycemia in patients with hemolytic anemia, including compensatory anemia, low HbA1c levels along with negative results for conventional hemolysis indicators have been reported in patients with latent hemolysis. Conversely, glycated albumin (GA) is a glycemic control indicator unaffected by hemolysis. Erythrocyte creatine (EC) is a hemolysis indicator that reflects the mean age of red blood cells (MTwo patients with latent hemolysis and low HbA1c values relative to glycemia were investigated, while controls comprised 214 patients (including patients with hemolysis and/or type 2 diabetes mellitus). HbA1c was expressed in International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) units (iA1c). GA/iA1c ratios, reticulocyte counts, EC, and MBoth reticulocyte counts and haptoglobin levels were within reference ranges in patients with latent hemolysis. GA/iA1c ratios and EC were higher than reference values in patients with latent hemolysis, and MEC measurement and M
Databáze: OpenAIRE