Clinical experience of stereotactic radiosurgery at a linear accelerator for intraocular melanoma
| Autor: | Alena Furdova, M Chorváth, Gabriel Kralik, Robert Furda, Michal Greguš, M Sramka |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Uveal Neoplasms Cancer Research Dose-volume histogram medicine.medical_specialty Skin Neoplasms medicine.medical_treatment Enucleation Dermatology Radiosurgery 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine medicine Humans Medical physics Stage (cooking) Melanoma Retrospective Studies business.industry Ciliary body melanoma Retrospective cohort study medicine.disease Survival Rate Treatment Outcome Oncology 030220 oncology & carcinogenesis 030221 ophthalmology & optometry Female Radiology business |
| Zdroj: | Melanoma Research. 27:463-468 |
| ISSN: | 0960-8931 |
| DOI: | 10.1097/cmr.0000000000000364 |
| Popis: | Long-term results with linear accelerator LINAC-based stereotactic radiosurgery for intraocular uveal malignant melanoma were assessed. A retrospective study was carried out of patients with uveal melanoma after a 1-day session stereotactic radiosurgery at LINAC in Slovakia. In the period 2001-2015, a group of 150 patients with uveal melanoma (139 choroidal melanoma, 11 ciliary body melanoma) was treated. The median tumor volume at baseline was 0.5 cm (with range from 0.2 to 1.6 cm). Tumors ranged in size from 2.4 to 20.8 mm in basal diameter and from 2.0 to 18.3 mm in thickness. The therapeutic dose was 35.0 Gy by 99% of dose volume histogram. Older age at treatment was correlated with the largest basal tumor diameter, tumor thickness, and TNM stage. The survival after stereotactic irradiation was 96% in 1 year, 93% in 2 years, 84% in 5 years, 80% in 7 years, and 53% in 11 years. In 20 (13.3%) patients, secondary enucleation was necessary because of complications (secondary glaucoma). Enucleation-free interval ranged from 1 to 6 years. The median age at death was lower (65.7 years) for patients who died from metastatic disease than for those who died from any other cause (75.0 years). Survival rates at 5-year intervals and the need for secondary enucleation because of complications after linear accelerator irradiation are comparable to other techniques. |
| Databáze: | OpenAIRE |
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