Magnetic Force Microscopy Characterization of Superparamagnetic Iron Oxide Nanoparticles (SPIONs)
Autor: | Simon J. Attwood, Ravi Gaikwad, Gustavo Cordova, Frank X. Gu, Zoya Leonenko |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Materials science
Dispersity Biomedical Engineering FOS: Physical sciences Nanoparticle 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention law Zeta potential medicine Physics - Biological Physics Filtration Factorial experiment 021001 nanoscience & nanotechnology equipment and supplies 0104 chemical sciences Chemical engineering Biological Physics (physics.bio-ph) Poloxamer 407 Particle Particle size 0210 nano-technology human activities medicine.drug |
Popis: | The present study was aimed to develop dimethylaminoethyl methacrylate based nanoparticulate drug delivery system using nanoprecipitation method and optimize the process parameters using Plackett-Burman factorial design to yield least average particle size and narrow sized particle distribution without filtration or centrifugation process. Twelve experimental runs involving 11 process parameters at higher and lower levels were generated using Design-Expert. Factorial design result has shown that (a) Except stirring duration all other process parameters significantly influence the average particle size; (B) Except β-cyclodextrin concentration, aqueous phase volume and organic phase volume, all other process parameters significantly influence the polydispersity index; and (C) Except polymer concentration and poloxamer 407 concentration, all other process parameters do not significantly influence the zeta potential. The average particle size, polydispersity index and zeta potential of the prepared dual drug loaded nanoparticles were well within acceptable limits and found to be in the range of 47 to 87 nm, 0.14 to 0.28 and 22 to 39 mV, respectively. Surface morphology examination has shown that the prepared nanoparticles were spherical in shape. The developed dimethylaminoethyl methacrylate based nanoparticulate drug delivery system can be routinely used to fabricate narrow sized polymeric nanoparticles without filtration or centrifugation process. |
Databáze: | OpenAIRE |
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