Proangiogenic features in chronic pelvic pain caused by adenomyosis

Autor:	Marina Lebedeva, M. A. Sounov, V E Radzinsky, Mekan R. Orazov, M.B. Khamoshina, E N Nosenko
Rok vydání:	2016
Předmět:	Vascular Endothelial Growth Factor A 0301 basic medicine medicine.medical_specialty Pathology Angiogenesis Endocrinology Diabetes and Metabolism VEGF receptors Neovascularization Physiologic Pelvic Pain Endometrium 03 medical and health sciences chemistry.chemical_compound Endocrinology medicine Humans In patient Adenomyosis reproductive and urinary physiology Gynecology biology urogenital system business.industry Pelvic pain Uterus Myometrium Obstetrics and Gynecology medicine.disease female genital diseases and pregnancy complications Vascular endothelial growth factor 030104 developmental biology medicine.anatomical_structure chemistry biology.protein Female Chronic Pain medicine.symptom business
Zdroj:	Gynecological Endocrinology. 32:7-10
ISSN:	1473-0766 0951-3590
Popis:	The study of peculiarities of expression of vascular endothelial growth factor (VEGF) in the tissues of the endometrium and myometrium in patients with adenomyosis, associated with chronic pelvic pain syndrome.Uterus macro-preparations obtained after hysterectomy in 60 patients with pelvic pain on a background of diffuse adenomyosis II-III degree were used for morphological examination, and macro-preparations received from 30 women with adenomyosis without pain syndrome. The diagnosis of adenomyosis was confirmed by sonography and magnetic resonance imaging. The expression of VEGF in tissues of the endometrium and myometrium was determined using the immune-histochemical method. The significance of differences of the compared parameters was determined using the criterion of Wilcoxon and Mann-Whitney. The differences were considered statistically significant when p 0.05.It was found that a higher expression of VEGF is characteristic for patients with pelvic pain associated with adenomyosis, compared to women with adenomyosis and abnormal uterine bleeding, both in epithelial cells of ectopic endometrium (14.7 ± 1.6% against 10.7 ± 1.6%, p 0.01), and in smooth myocytes of the myometrium (12.6 ± 1.4% against 9.6 ± 1.2%, p 0.01) and in the stromal cells of the myometrium (10.1 ± 1.9% versus 7.4 ± 1.8%, p 0.01).An increased expression of VEGF in the tissues of the uterus is one of the most important pathogenetic mechanisms of algogenesis with adenomyosis, associated syndrome of chronic pelvic pain, compared to the silent form of the disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8559338d7a6033eafd0ff6de502241 https://doi.org/10.1080/09513590.2016.1232902 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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