Tubulointerstitial injury and the progression of chronic kidney disease
| Autor: | H. William Schnaper, Kavita S. Hodgkins |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Nephrology
medicine.medical_specialty Pathology 030232 urology & nephrology Renal function Inflammation Cell Communication Pediatrics 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine Medicine & Public Health medicine Humans Hypoxia Renal stem cell Educational Review 030304 developmental biology Feedback Physiological 0303 health sciences business.industry Hypoxia (medical) medicine.disease 3. Good health Proteinuria Kidney Tubules Chronic Disease Pediatrics Perinatology and Child Health Disease Progression Nephritis Interstitial Kidney Diseases medicine.symptom business Nephritis Signal Transduction Kidney disease |
| Zdroj: | Pediatric Nephrology (Berlin, Germany) |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-011-1992-9 |
| Popis: | In chronic kidney disease (CKD), once injury from any number of disease processes reaches a threshold, there follows an apparently irreversible course toward decline in kidney function. The tubulointerstitium may play a key role in this common progression pathway. Direct injury, high metabolic demands, or stimuli from various other forms of renal dysfunction activate tubular cells. These, in turn, interact with interstitial tissue elements and inflammatory cells, causing further pathologic changes in the renal parenchyma. The tissue response to these changes thus generates a feed-forward loop of kidney injury and progressive loss of function. This article reviews the mechanisms of this negative cycle mediating CKD. |
| Databáze: | OpenAIRE |
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