The effect of inducible nitric oxide synthase on postoperative adhesion formation in rats
| Autor: | Mustafa Kaplanoglu, Gürkan Yazici, Duygu Düsmez Apa, Meral Aban, Utku Oz, Özlem Pata, Saffet Dilek, Ekrem C. Tok |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Nitric Oxide Synthase Type II Inflammation Tissue Adhesions Peritoneal Diseases Nitric oxide Lesion chemistry.chemical_compound Postoperative Complications Fibrosis Internal medicine medicine Animals Enzyme Inhibitors Rats Wistar chemistry.chemical_classification biology business.industry Obstetrics and Gynecology Postoperative adhesion Adhesion medicine.disease Acetylcysteine Rats Nitric oxide synthase Disease Models Animal Enzyme Endocrinology Reproductive Medicine chemistry Immunology biology.protein Female medicine.symptom Nitric Oxide Synthase Peritoneum business |
| Zdroj: | European journal of obstetrics, gynecology, and reproductive biology. 117(1) |
| ISSN: | 0301-2115 |
| Popis: | To evaluate the effect of iNOS on adhesion formation and to assess whether inhibition of iNOS expression affected adhesion formation according to adhesion maturation days.Forty Wistar Albino rats were subjected to standardized lesion by cecal abrasion and parietal peritoneal defect and were randomly divided into four groups. Group I (control) received no treatment; groups II-IV received N-acetyl-cystein (NAC) 15 mg/100 g per day intramuscularly on days 4-14, 0-14 and 0-3, respectively, after surgery. On the postoperative 14th day adhesion score, tissue iNOS expression, inflammatory cell reaction (ICR) and tissue fibrosis score were determined.Inflammation score of groups I and II was lower than that of groups III and IV (P0.05). Adhesion scores and tissue fibrosis of group II were significantly lower than that of the other groups (P0.001).iNOS inhibition during the first 3 days postoperatively caused a delay in the resolution of inflammatory cell reaction. On the other hand, when inhibited after the first 3 days, adhesion formation and fibrosis were reduced both clinically and histopathologically. |
| Databáze: | OpenAIRE |
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