Effect of norfloxacin, trimethoprim-sulfamethoxazole and nitrofurantoin on fecal flora of women with recurrent urinary tract infections
| Autor: | E. Mavromanolakis, Yiannis Tselentis, George Samonis, A. Cranidis, Sofia Maraki |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
medicine.medical_specialty medicine.drug_class Antibiotics Anti-Infective Agents Urinary urologic and male genital diseases Gastroenterology Microbiology Feces Enterobacteriaceae Recurrence Internal medicine Trimethoprim Sulfamethoxazole Drug Combination medicine Humans Pharmacology (medical) Prospective Studies Norfloxacin Antibacterial agent Pharmacology biology business.industry Sulfamethoxazole Middle Aged bacterial infections and mycoses Antimicrobial biology.organism_classification Trimethoprim Infectious Diseases Oncology Enterococcus Nitrofurantoin Urinary Tract Infections Female business medicine.drug |
| Zdroj: | Journal of chemotherapy (Florence, Italy). 9(3) |
| ISSN: | 1120-009X |
| Popis: | The effects of antibiotics used for prophylaxis in women with recurrent urinary tract infections (UTIs) on the aerobic intestinal flora were investigated. Twenty-one patients with recurrent UTIs were randomly divided into three groups. The patients of each group received monotherapy with oral norfloxacin, trimethoprim-sulfamethoxazole or nitrofurantoin for one month. Urine and stool quantitative aerobic cultures were performed before prophylaxis, 2 and 4 weeks after the initiation of therapy, and 2 weeks after antibiotics were discontinued. The gram-negative aerobic flora was strongly suppressed during the administration of norfloxacin and trimethoprim-sulfamethoxazole, while Enterococcus spp. were not affected. Resistant strains of Escherichia coli were detected in two patients, one in the norfloxacin and one in the trimethoprim-sulfamethoxazole group. The aerobic intestinal flora was not affected by nitrofurantoin. These findings help in the selection of the most appropriate antimicrobial agent for prophylaxis in recurrent UTIs, so as to reduce the possibility of emergence of resistant bacterial strains. |
| Databáze: | OpenAIRE |
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