Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight
| Autor: | Sudeshna Mukherjee, K. Lohitesh, Rajdeep Chowdhury |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Apoptosis Review Disease lcsh:RC254-282 Metastasis Causes of cancer 03 medical and health sciences 0302 clinical medicine Internal medicine Genetics medicine Autophagy HCC lcsh:QH573-671 Cancer Chemotherapy business.industry lcsh:Cytology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma Stem cell Liver cancer business Chemoresistance |
| Zdroj: | Cancer Cell International, Vol 18, Iss 1, Pp 1-15 (2018) Cancer Cell International |
| ISSN: | 1475-2867 |
| Popis: | Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality, accounting for almost 90% of total liver cancer burden. Surgical resection followed by adjuvant and systemic chemotherapy are the most meticulously followed treatment procedures but the complex etiology and high metastatic potential of the disease renders surgical treatment futile in majority of the cases. Another hindrance to the scenario is the acquired resistance to drugs resulting in relapse of the disease. Hence, to provide insights into development of novel therapeutic targets and diagnostic biomarkers, this review focuses on the various molecular mechanisms underlying chemoresistance in HCC. We have provided a comprehensive summary of the various strategies adopted by HCC cells, extending from apoptosis evasion, autophagy activation, drug expulsion to epigenetic transformation as modes of therapy resistance. The role of stem cells in imparting chemoresistance is also discussed. Furthermore, the review also focuses on how this knowledge might be exploited for the development of an effective, prospective therapy against HCC. |
| Databáze: | OpenAIRE |
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