Histopathologic studies of DMBA-induced mouse submandibular-gland tumors with or without cryoprobe treatment
| Autor: | Noriyasu Murase, Hyun Kh, Y. Takai, Matsuji Hosaka, Masahiko Mori |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Time Factors Adenoma 9 10-Dimethyl-1 2-benzanthracene medicine.medical_treatment Submandibular Gland Adenoma Pleomorphic DMBA Cryosurgery Pathology and Forensic Medicine Malignant transformation Pleomorphic adenoma Mice stomatognathic system Benz(a)Anthracenes medicine Animals Fibrosarcoma business.industry Neoplasms Experimental Salivary Gland Neoplasms medicine.disease Submandibular gland Squamous metaplasia Submandibular Gland Neoplasms stomatognathic diseases Cell Transformation Neoplastic medicine.anatomical_structure Otorhinolaryngology Carcinoma Squamous Cell Periodontics Oral Surgery business Precancerous Conditions |
| Zdroj: | Journal of Oral Pathology and Medicine. 13:419-428 |
| ISSN: | 1600-0714 0904-2512 |
| DOI: | 10.1111/j.1600-0714.1984.tb01442.x |
| Popis: | Histopathologic observations of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced tumors in the mouse submandibular glands are reported using cryoprobe treatment. The experimental animals were divided into 2 groups; one received a carcinogen injection into the normal submandibular gland, and the other was injected with DMBA on the 14th day following cryosurgery of the gland using a -60 degrees C cryoprobe. Pathologic findings were classified as premalignant lesions or squamous-cell carcinomas with varying degrees of keratinization, fibrosarcoma and mixed carcinoma. There was also one case each of malignant pleomorphic adenoma and cystic adenoma. Tumor incidence was nearly the same in the 2 groups. Most of the carcinomas and sarcomas in the submandibular gland were induced during the 12th and 17th weeks. DMBA application during the proliferating stage which followed the cryosurgery did not enhance epithelial-tumor induction. During submandibular gland carcinogenesis, alterations in the granular convoluted tubule cells suggests they were the initial target cells undergoing malignant transformation. Squamous-cell carcinomas with varying degrees of keratinization were induced following squamous metaplasia in duct-like structures or multicystic lesions. |
| Databáze: | OpenAIRE |
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