Molecular Epidemiology and Complete Genome Characterization of H1N1pdm Virus from India

Autor: P. V. L. Rao, Maria Thomas, Paban Kumar Dash, Ishan K. Patro, Gaurav Joshi, Jyoti S. Kumar, Anita Desai, Shashi Sharma, Manmohan Parida, T.N. Athmaram, Ravi Vasanthapuram
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Viral Diseases
Internationality
Genes
Viral
Epidemiology
viruses
lcsh:Medicine
medicine.disease_cause
Genome
Influenza A Virus
H1N1 Subtype
Emerging Viral Diseases
Pandemic
Influenza A virus
Genome Sequencing
Clade
lcsh:Science
Child
Genome Evolution
Phylogeny
Molecular Epidemiology
Multidisciplinary
Genomics
Middle Aged
Phylogenetics
Infectious Diseases
Medical Microbiology
Viral evolution
Child
Preschool
Medicine
Female
Research Article
Adult
Adolescent
India
Biology
Microbiology
Virus
Viral Evolution
Infectious Disease Epidemiology
Evolution
Molecular
Young Adult
Genome Analysis Tools
Virology
medicine
Humans
Evolutionary Systematics
Selection
Genetic
Pandemics
Aged
Evolutionary Biology
Molecular epidemiology
Population Biology
lcsh:R
Outbreak
Infant
Comparative Genomics
Influenza
Viral Disease Diagnosis
Emerging Infectious Diseases
Mutation
lcsh:Q
Viral Transmission and Infection
Zdroj: PLoS ONE
PLoS ONE, Vol 8, Iss 2, p e56364 (2013)
ISSN: 1932-6203
Popis: Background Influenza A virus is one of world’s major uncontrolled pathogen, causing seasonal epidemic as well as global pandemic. This was evidenced by recent emergence and continued prevalent 2009 swine origin pandemic H1N1 Influenza A virus, provoking first true pandemic in the past 40 years. In the course of its evolution, the virus acquired many mutations and multiple unidentified molecular determinants are likely responsible for the ability of the 2009 H1N1 virus to cause increased disease severity in humans. Availability of limited data on complete genome hampers the continuous monitoring of this type of events. Outbreaks with considerable morbidity and mortality have been reported from all parts of the country. Methods/Results Considering a large number of clinical cases of infection complete genome based sequence characterization of Indian H1N1pdm virus and their phylogenetic analysis with respect to circulating global viruses was undertaken, to reveal the phylodynamic pattern of H1N1pdm virus in India from 2009–2011. The Clade VII was observed as a major circulating clade in phylogenetic analysis. Selection pressure analysis revealed 18 positively selected sites in major surface proteins of H1N1pdm virus. Conclusions This study clearly revealed that clade VII has been identified as recent circulating clade in India as well globally. Few clade VII specific well identified markers undergone positive selection during virus evolution. Continuous monitoring of the H1N1pdm virus is warranted to track of the virus evolution and further transmission. This study will serve as a baseline data for future surveillance and also for development of suitable therapeutics.
Databáze: OpenAIRE
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