Evidence based medicine in the use of botulinum toxin for back pain
| Autor: | B. Jabbari |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Botulinum Toxins Neurology Activities of daily living Back pain Erector spinae muscles Humans Medicine Prospective cohort study Biological Psychiatry Pain Measurement Evidence-Based Medicine Anti-Dyskinesia Agents business.industry Evidence-based medicine Low back pain Botulinum toxin Psychiatry and Mental health Back Pain Anesthesia Physical therapy Neurology (clinical) medicine.symptom business medicine.drug |
| Zdroj: | Journal of Neural Transmission. 115:637-640 |
| ISSN: | 1435-1463 0300-9564 |
| DOI: | 10.1007/s00702-007-0864-8 |
| Popis: | Two randomized, prospective studies, one double blind and one open label, longterm evaluated efficacy and safety of Botulinum toxin A (Allergan-Inc) in 31 and 75 patients with chronic low back pain. Both studies used a novel technique imploying 5 level (L1 to L5) injections (40–50 units/level) of BoNT-A into erector spinae muscles. Significant (p < 0.05) improvement of pain intensity, frequency and activities of daily living was noted in 60% and 53% of the patients, respectively. The second study also depicted safety with repeated injections over 14 months of follow up. Botulinum toxin-A should be considered for treatment of low back pain when other modes of treatment fail to improve pain. |
| Databáze: | OpenAIRE |
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