Maternal obesity attenuates predelivery inflammatory reaction in C57BL/6N mice
| Autor: | Maria Wohlfarth, Merle Schulze-Edinghausen, Kai-Dietrich Nüsken, Jörg Dötsch, Malte Heykants, Esther Mahabir, Sarah Appel, Sarah Storck, Ruth Janoschek, Tobias Kretschmer, Marion Handwerk, Inga Bae-Gartz, Eva Hucklenbruch-Rother |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Placenta Immunology Adipose tissue Inflammation White adipose tissue Biology medicine.disease_cause 03 medical and health sciences Mice Pregnancy Internal medicine medicine Immunology and Allergy Animals Humans Obesity Cells Cultured Obstetrics and Gynecology medicine.disease Diet Mice Inbred C57BL Disease Models Animal Oxidative Stress 030104 developmental biology medicine.anatomical_structure Endocrinology Reproductive Medicine Prenatal Exposure Delayed Effects Female medicine.symptom Inflammation Mediators Infiltration (medical) Oxidative stress |
| Zdroj: | Journal of reproductive immunology. 122 |
| ISSN: | 1872-7603 |
| Popis: | Inflammation and oxidative stress are known to increase before labour. Whether gonadal white adipose tissue (gWAT) participates in this process and whether labour-related processes in placental and adipose tissue are altered in obese women is unknown. In our mouse model, lean mice display elevated placental inflammation and oxidative stress towards the end of pregnancy, accompanied by an increased expression of pro-inflammatory factors in gWAT. Obese mice also display elevated levels of pro-inflammatory factors and oxidative stress in placentas shortly before birth. However, placental infiltration with leukocytes and an increase in gWAT pro-inflammatory factor expression in obese dams are lacking. |
| Databáze: | OpenAIRE |
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