A Model of a Zebrafish Avatar for Co-Clinical Trials
| Autor: | Gregorio Di Franco, Patrizia Colucci, Alfredo Falcone, Le Pollina, Vittoria Raffa, Enrico Vasile, Matteo Palmeri, Niccola Funel, Luca Morelli, Luciana Dente, Alice Usai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty equivalent dose patient-derived xenograft Translational research lcsh:RC254-282 Article zebrafish avatar Efficacy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Zebrafish Avatar biology Adult patients chemosensitivity translational research business.industry lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens biology.organism_classification Clinical trial 030104 developmental biology 030220 oncology & carcinogenesis Personalized medicine business Dose conversion |
| Zdroj: | Cancers Volume 12 Issue 3 Cancers, Vol 12, Iss 3, p 677 (2020) |
| Popis: | Animal &ldquo avatars&rdquo and co-clinical trials are being developed for possible use in personalized medicine in oncology. In a co-clinical trial, the cancer cells of the patient&rsquo s tumor are xenotransplanted into the animal avatar for drug efficacy studies, and the data collected in the animal trial are used to plan the best drug treatment in the patient trial. Zebrafish have recently been proposed for implementing avatar models, however the lack of a general criterion for the chemotherapy dose conversion from humans to fish is a limitation in terms of conducting co-clinical trials. Here, we validate a simple, reliant and cost-effective avatar model based on the use of zebrafish embryos. By crossing data from safety and efficacy studies, we found a basic formula for estimating the equivalent dose for use in co-clinical trials which we validated in a clinical study enrolling 24 adult patients with solid cancers (XenoZ, NCT03668418). |
| Databáze: | OpenAIRE |
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