Computer-aided discovery of biological activity spectra for anti-aging and anti-cancer olive oil oleuropeins
| Autor: | Vicente Micol, Bruna Corominas-Faja, Antonio Segura-Carretero, Elvira Santangelo, Xavier Ariza, Jordi Garcia, Jorge Joven, Elisabet Cuyàs, Javier A. Menendez |
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| Přispěvatelé: | Medicina i Cirurgia, Universitat Rovira i Virgili., Universitat de Barcelona |
| Rok vydání: | 2014 |
| Předmět: |
Bioquímica
Aging Programari Iridoid Glucosides decarboxymethyl oleuropein aglycone Biochemistry Medicaments antineoplàstics chemistry.chemical_compound Theory Article Oleuropein Envelliment Drug Discovery Antineoplastic agents medicine Plant Oils cancer Iridoids Computer software Càncer Olive Oil Cancer Drug discovery Plant Extracts Polyphenols Biological activity Cell Biology medicine.disease Antineoplastic Agents Phytogenic PASS oleuropein aglycone Oli d'oliva Aglycone chemistry Polyphenol Biological activity spectra Olive oil |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Aging (Albany NY) Aging Repositori Institucional de la Universitat Rovira i Virgili Universitat Rovira i virgili (URV) ResearcherID Recercat. Dipósit de la Recerca de Catalunya instname Scopus-Elsevier Europe PubMed Central |
| DOI: | 10.18632/aging.100691 |
| Popis: | Aging is associated with common conditions, including cancer, diabetes, cardiovascular disease, and Alzheimer's disease. The type of multi-targeted pharmacological approach necessary to address a complex multifaceted disease such as aging might take advantage of pleiotropic natural polyphenols affecting a wide variety of biological processes. We have recently postulated that the secoiridoids oleuropein aglycone (OA) and decarboxymethyl oleuropein aglycone (DOA), two complex polyphenols present in health-promoting extra virgin olive oil (EVOO), might constitute a new family of plant-produced gerosuppressant agents. This paper describes an analysis of the biological activity spectra (BAS) of OA and DOA using PASS (Prediction of Activity Spectra for Substances) software. PASS can predict thousands of biological activities, as the BAS of a compound is an intrinsic property that is largely dependent on the compound's structure and reflects pharmacological effects, physiological and biochemical mechanisms of action, and specific toxicities. Using Pharmaexpert, a tool that analyzes the PASS-predicted BAS of substances based on thousands of 'mechanism-effect' and 'effect-mechanism' relationships, we illuminate hypothesis-generating pharmacological effects, mechanisms of action, and targets that might underlie the anti-aging/anti-cancer activities of the gerosuppressant EVOO oleuropeins. |
| Databáze: | OpenAIRE |
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