Genome editing for disease resistance in pigs and chickens
| Autor: | Christine Tait-Burkard, Christopher Proudfoot, Simon G. Lillico |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
disease resistance Disease Breeding Biology Plant disease resistance Selective breeding Genome 03 medical and health sciences Food Animals Genome editing genome editing Disease Resistance 2. Zero hunger Resistance (ecology) business.industry 0402 animal and dairy science British Agricultural Revolution pigs 04 agricultural and veterinary sciences 040201 dairy & animal science Feature Articles Biotechnology 030104 developmental biology breeding chickens Pigs Animal Science and Zoology Livestock business Chickens |
| Zdroj: | Animal Frontiers: The Review Magazine of Animal Agriculture Proudfoot, C, Lillico, S & Tait-Burkard, C 2019, ' Genome editing for disease resistance in pigs and chickens ', Animal Frontiers . https://doi.org/10.1093/af/vfz013 Animal Frontiers |
| ISSN: | 2160-6064 2160-6056 |
| DOI: | 10.1093/af/vfz013 |
| Popis: | For thousands of years, humans have used selective breeding to improve desirable traits in both livestock and companion animals. In livestock, targeted breeding has been common practice since the British Agricultural Revolution of the 18th century, with measurable production traits such as feed conversion in cattle or wool production in sheep actively selected for. In the late 20th century, genomic selection was added to the livestock breeding tool box; by reading specific locations in the genome and assigning them to measurable production traits, faster improvement in livestock production efficiency has been achieved. One of the inherently difficult production traits to measure is resistance to a specific disease, as animals with less severe symptoms or pathology may simply have been exposed to less pathogen. Experimental infections guaranteeing equal pathogen exposures are expensive and require large numbers of animals for genetic association studies, making them ethically questionable. Genome editing offers new opportunities to livestock breeding for disease resistance, allowing the direct translation of laboratory research into disease-resistant or resilient animals. |
| Databáze: | OpenAIRE |
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