Expression of NF-κB in Helicobacter pylori Infection
| Autor: | Vahit Yukselen, Zehra Kocakaya Erkul, Pınar Okyay, Ibrahim Meteoglu, Esra Ozkara, Furuzan Kacar Doger |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Pathology Physiology Biopsy Spirillaceae Chronic gastritis Severity of Illness Index Gastroenterology Helicobacter Infections Atrophy Internal medicine Metaplasia medicine Gastric mucosa Humans Retrospective Studies Helicobacter pylori biology business.industry NF-kappa B Intestinal metaplasia Epithelial Cells Gene Expression Regulation Bacterial medicine.disease biology.organism_classification medicine.anatomical_structure Gastric Mucosa Gastritis medicine.symptom business |
| Zdroj: | Digestive Diseases and Sciences. 51:2306-2309 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | Helicobacter pylori colonizes the gastric mucosa in humans and causes chronic gastritis. NF-kappaB has a key role as a mediator in mucosal inflammation. In this study, we examined the expression of NF-kappaB in the antral epithelial cells of H. pylori-infected and H. pylori-uninfected biopsies and examined these processes in relationship with grade and activity of gastritis, density of H. pylori, presence of the intestinal metaplasia, and atrophy. Fifty biopsies (35 H. pylori-positive patients and 15 H. pylori-negative controls) were studied. NF-kappaB immunohistochemical stain was performed. NF-kappaB activity in H. pylori-infected biopsies were markedly enhanced compared with uninflamed biopsies (P = 0.001). We also found positive correlation NF-kappaB expression with severity of gastritis (according to Sydney score) (P = 0.001), activity of gastritis (P = 0.046) and H. pylori load (P < 0.001), and atrophy (P = 0.004). We did not find a significant relationship between NF-kappaB and the presence of intestinal metaplasia (P = 0.355). These findings suggested that expression of NF-kappaB has an important role in H. pylori gastritis. |
| Databáze: | OpenAIRE |
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