Is oxidative stress related to childhood urolithiasis?
| Autor: | Emel Torun, Aysegul Dogan Demir, Faruk Öktem, Nilüfer Göknar, Engin Ari |
|---|---|
| Přispěvatelé: | TORUN, EMEL |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Turkey Urinary system Urology Urine Kidney Function Tests urologic and male genital diseases medicine.disease_cause Antioxidants Urolithiasis Acetylglucosaminidase medicine Humans Hypercalciuria Child Göknar N. Oktem F. Arı E. Demir A. Torun E. -Is oxidative stress related to childhood urolithiasis?- Pediatric nephrology (Berlin Germany) cilt.29 ss.1381-6 2014 business.industry medicine.disease Hyperuricosuria Oxidative Stress Nephrology Child Preschool Creatinine Pediatrics Perinatology and Child Health Female Microalbuminuria Kidney stones business Hypocitraturia Oxidative stress |
| Zdroj: | Pediatric Nephrology. 29:1381-1386 |
| ISSN: | 1432-198X 0931-041X |
| DOI: | 10.1007/s00467-014-2773-z |
| Popis: | Urolithiasis is a common condition in pediatric populations in Turkey. The role of oxidative stress in renal stone formation in pediatric patients has not been reported to date. The aim of this study was to assess oxidative stress in childhood urolithiasis. Seventy-four children diagnosed with urolithiasis and 72 healthy control subjects were enrolled in the study. Kidney stone formers were evaluated by analysis of metabolic conditions related to urolithiasis, such as hypercalciuria, hyperoxaluria, hypocitraturia and hyperuricosuria. Urine total antioxidant status (TAS), and total oxidant status (TOS) were measured, and oxidative stress index (OSI) was calculated as an indicator of the degree of oxidative stress. Among the stone formers, metabolic analyses revealed that 30 % had hypercalciuria, 45 % had hypocitraturia, 6 % had hyperoxaluria and 40 % had hyperuricosuria. Elevated levels of the renal tubular damage marker urinary N-acetyl- beta-d-glucosaminidase (NAG) was elevated in 25 % of the patient group, but microalbuminuria was not detected. Total oxidant status and total antioxidant status were significantly higher in stone formers than in the controls (p = 0.023 and 0.004, respectively). In addition, urinary NAG was significantly correlated with TOS (r = 0.427, p = 0.019). The results of this study show that oxidative stress may play an important role in the pathogenesis of pediatric stone formers. |
| Databáze: | OpenAIRE |
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