Growth Inhibition of Colon Cancer and Melanoma Cells by Versiol Derivatives from a Paraconiothyrium Species
| Autor: | John A. Beutler, Trong D. Tran, Namki Cho, Janet M. Sigmund, Robert H. Cichewicz, Michael Goetz, Tanya T. Ransom |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Colorectal cancer
Pharmaceutical Science Fungus Naphthalenes Inhibitory postsynaptic potential 01 natural sciences Article Analytical Chemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ascomycota Cell Line Tumor Drug Discovery medicine Humans Melanoma Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure biology 010405 organic chemistry Cell growth Organic Chemistry biology.organism_classification medicine.disease Molecular biology 0104 chemical sciences Complementary and alternative medicine Biochemistry chemistry Cell culture 030220 oncology & carcinogenesis Colonic Neoplasms Molecular Medicine Growth inhibition Heterocyclic Compounds 3-Ring Two-dimensional nuclear magnetic resonance spectroscopy Algorithms |
| Zdroj: | Journal of Natural Products. 80:2037-2044 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Bioassay-guided fractionation of a colon cancer growth inhibitory extract of the fungus Paraconiothyrium sp. led to the isolation of eight new versiol derivatives (1, 3-8, 10) along with two known compounds. The structures were elucidated by interpretation of combined MS and 2D NMR spectroscopic data. Compounds 8, 9, and 10 showed cell growth inhibition against COLO205 and KM12 cells, and both 8 and 9 displayed selectivity in their inhibition of melanoma cell lines in the NCI 60 one-dose test. In addition, compound 8 and the crude Paraconiothyrium sp. extract showed potent dose-dependent inhibitory effects in the five-dose NCI 60 cell line assay. |
| Databáze: | OpenAIRE |
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