Emergence and clinical insights into the pathology of Chikungunya virus infection
| Autor: | Jean Jacques Hoarau, Stéphanie Robin, Anne Ribera, Duksha Ramful, Marie Christine Jaffar-Bandjee, Bernard Alex Gaüzère, Philippe Gasque, Jimmy Selambarom, Pascale Krejbich-Trotot |
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| Přispěvatelé: | Groupe de Recherche en Immunopathologies et maladies infectueuses (GRI), Université de La Réunion (UR)-Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion], Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Laboratoire de Chimie des Substances Naturelles et des Sciences des Aliments (LCSNSA), Université de La Réunion (UR), Laboratoire de Biochimie et Génétique Moléculaire (LBGM) |
| Rok vydání: | 2010 |
| Předmět: |
Male
Microbiology (medical) Pathology medicine.medical_specialty [SDV]Life Sciences [q-bio] Disease Global Health medicine.disease_cause Communicable Diseases Emerging Microbiology Aedes Pregnancy Virology Global health medicine Animals Humans Chikungunya Pregnancy Complications Infectious biology Alphavirus Infections business.industry Transmission (medicine) Vaccination virus diseases Tropical disease Viral Vaccines biology.organism_classification medicine.disease Rash Insect Vectors 3. Good health Infectious Diseases Insect Repellents Encephalitis Female medicine.symptom business Chikungunya virus |
| Zdroj: | Expert Review of Anti-infective Therapy Expert Review of Anti-infective Therapy, Expert Reviews, 2010, 8 (9), pp.987--996. ⟨10.1586/eri.10.92⟩ |
| ISSN: | 1744-8336 1478-7210 |
| DOI: | 10.1586/eri.10.92 |
| Popis: | International audience; Major epidemics of Chikungunya have re-emerged with millions of cases worldwide. What was once largely a tropical disease in poorer countries is now recognized as a major global health issue. The disease is perpetuated by the alphavirus Chikungunya, and is transmitted by Aedes mosquitoes. The infection is highly symptomatic, with fever, skin rash and incapacitating arthralgia, which can evolve to chronic arthritis and rheumatism in elderly patients. Mother-to-child transmission, encephalitis, Guillain–Barré syndrome and deaths have been noted. In this article, we will highlight the epidemiological, clinical, virological and immunological aspects of the disease and mention the therapies that have been used during recent epidemics. Novel prevention measures to control the mosquito and a new vaccine are highly warranted. |
| Databáze: | OpenAIRE |
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