Decreased beating rate variability of cultured cardiomyocytes by endotoxin
| Autor: | Ursula Müller-Werdan, Karl Werdan, Hendrik Schmidt |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Beating rate
Pathology medicine.medical_specialty Poor prognosis Neonatal rat Decreased heart rate business.industry Critically ill Critical Care and Intensive Care Medicine Nitric oxide chemistry.chemical_compound Endocrinology chemistry Internal medicine Healthy volunteers Meeting Abstract Medicine Heart rate variability business |
| Zdroj: | Critical Care |
| ISSN: | 1466-609X 1364-8535 |
| Popis: | A decreased heart rate variability is a marker of autonomic dysfunction and indicates poor prognosis in critically ill patients. In healthy volunteers, such a decreased heart rate variability can he reversibly induced by i.v. administration of endotoxin (Crit Care Med 24 :1117-1124). It is unknown if this effect is due to a direct impact of endotoxin on the heart, or if secondary release products are responsible herefore. Using isolated, spontaneously contracting neonatal rat cardiomyocytes (CM) we investigated if endotoxin narrows beating rate variability directly. |
| Databáze: | OpenAIRE |
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