High delayed mortality after the first episode of Clostridium difficile infection
| Autor: | Dácil García, Alfonso Perales, Teresa Marrodán, Antonio Ramos-Martínez, Cristina Badia, Javier Cobo, Aguirre Elena, Ferrere Federico, Pedro Llinares, Alberto Cózar, Cristina Sardiña, Luis Torres, Alfonso Muriel, Elena Bereciartua, Sandra Cuellar, Isabel Fernández Morales, Alberto Delgado-Iribarren, Pedro A. De Santos-Castro, Livia Giner, Ana Royuela, Martínez-Ruiz S. Rocío, Miguel Salavert, Luis A. Sánchez Muñoz, Antonio Sánchez-Porto, M. Teresa Pérez-Rodríguez, Pilar Mairal, Juan Gálvez-Acebal, Evelyn Shaw, Purificación Martos, Helena Gil-Campesino, César Henríquez, Esther Calbo, Cristina Martínez García, J. María Bravo-Ferrer, Castelo Laura, Esperanza Merino, Gonzalez Eva, AngelBratos-Pérez Miguel, Jose R. Romero, Jordi Cuquet |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Comorbidity Logistic regression Microbiology 03 medical and health sciences Internal medicine Fecal incontinence medicine Humans Prospective Studies Mortality 030304 developmental biology Aged First episode 0303 health sciences 030306 microbiology business.industry Mortality rate Clostridium difficile medicine.disease Survival Analysis Infectious Diseases Heart failure Cohort Clostridium Infections Female medicine.symptom business Immunosuppression |
| Zdroj: | ANAEROBE r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante instname Digital.CSIC. Repositorio Institucional del CSIC Anaerobe r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe |
| ISSN: | 1095-8274 1075-9964 |
| Popis: | Study group: José Romero; Alfonso Muriel; Livia Giner; Federico Ferrere; Rocío Martínez-Ruiz; Purificación Martos; Cristina Sardiña; Elena Aguirre; Cristina Badía; Alfonso Perales; Pedro A. De Santos-Castro; Angel Bratos-Pérez Miguel; Sandra Cuellar; Eva González; Pedro llinares; Laura Castelo; Isabel Morales; Alberto Delgado-Iribarren; Pilar Mairal Clostridium difficile infection (CDI) is characterized by a high delayed and unrelated mortality. Predicting delayed mortality in CDI patients could allow the implementation of interventions that could reduce these events. A prospective multicentric study was carried out to investigate prognostic factors associated with mortality. It was based on a cohort (July 2015 to February 2016) of 295 patients presenting with CDI. Logistic regression was used and the model was calibrated using the Hosmer-Lemeshow test. The mortality rate at 75 days in our series was 18%. Age (>65 years), comorbidity (defined by heart failure, diabetes mellitus with any organ lesion, renal failure, active neoplasia or immunosuppression) and fecal incontinence at clinical presentation were associated with delayed (75-day) mortality. When present, each of the aforementioned variables added one point to the score. Mortalities with 0, 1, 2 and 3 points were 0%, 9.4%, 18.5% and 38.2%, respectively. The area under the ROC curve was 0.743, and the Hosmer-Lemeshow goodness-of-fit test p value was 0.875. Therefore, the prediction of high delayed mortality in CDI patients by our scoring system could promote measures for increasing survival in suitable cases. |
| Databáze: | OpenAIRE |
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