The heart in massive (more than 300 pounds or 136 kilograms) obesity: analysis of 12 patients studied at necropsy
| Autor: | William C. Roberts, Carole A. Warnes |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Coronary Disease Coronary artery disease Internal medicine medicine Humans Myocardial infarction Obesity Coronary atherosclerosis Aortic dissection Intracerebral hemorrhage business.industry Myocardium Body Weight Age Factors Sleep apnea Organ Size Middle Aged medicine.disease Coronary Vessels Surgery Coronary arteries medicine.anatomical_structure Adipose Tissue Heart failure Cardiology Female Autopsy Cardiology and Cardiovascular Medicine business |
| Zdroj: | The American journal of cardiology. 54(8) |
| ISSN: | 0002-9149 |
| Popis: | Observations are described in 12 massively obese patients (5 women, 7 men), aged 25 to 59 years (mean 37), who weighed 312 to more than 500 pounds (mean 381). Seven patients had had systemic hypertension, 4 hypersomnia or sleep apnea, 2 diabetes mellitus, and 1 patient symptomatic coronary artery disease. Five patients died suddenly from undetermined causes, 2 from right-sided congestive heart failure, 1 patient from acute myocardial infarction; 1 from aortic dissection; 1 from intracerebral hemorrhage; 1 from a drug overdose, and 1 soon after an ileal bypass. The heart weight was increased in all 12 patients. The heart weight to body weight ratio expressed as a percent ranged from 0.22 to 0.61 (mean 0.37) (normal for men 0.42 to 0.46 [mean 0.43], normal for women 0.38 to 0.46 [mean 0.40]). The left ventricular cavity was dilated in 11 patients and the right ventricular cavity in all 12. Only 2 patients (aged 42 and 59 years) had 1 or more major epicardial coronary arteries narrowed >75% in cross-sectional area by atherosclerotic plaque, 1 of whom had no symptoms of myocardial ischemia. Of 664 five-millimeter segments from the 4 major epicardial coronary arteries from 11 patients (mean 60 per patient), 431 (65%) were narrowed 0 to 25% in XSA, 143 (21%) were narrowed 26 to 50%, 73 (11%) were narrowed 51 to 75%, and 17 (3%) were narrowed 76 to 100%. Thus, these extremely obese patients who died prematurely did not have more coronary atherosclerosis than might be expected at their ages. |
| Databáze: | OpenAIRE |
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