Full-width postlaminar optic nerve tumor invasion of retinoblastoma as risk-factor for leptomeningeal spread of retinoblastoma. A case report and review of the literature
| Autor: | Marcus C. de Jong, Paul van der Valk, Pim de Graaf, Jonas A. Castelijns, Floor Abbink, Annette C. Moll, Machteld I. Bosscha, Robin W. Jansen |
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| Přispěvatelé: | Radiology and nuclear medicine, Pathology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Pediatric surgery, CCA - Cancer Treatment and quality of life, Ophthalmology, ACS - Diabetes & metabolism, APH - Quality of Care, APH - Health Behaviors & Chronic Diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty genetic structures Retinal Neoplasms 030105 genetics & heredity Metastasis 03 medical and health sciences Fatal Outcome 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Neoplasm Invasiveness Child Genetics (clinical) Optic nerve tumor Pia mater Retinoblastoma business.industry Optic Nerve Neoplasms Leptomeninges medicine.disease eye diseases Ophthalmology medicine.anatomical_structure Pediatrics Perinatology and Child Health 030221 ophthalmology & optometry Optic nerve Resection margin sense organs business Meningeal Carcinomatosis Unilateral Retinoblastoma |
| Zdroj: | de Jong, M C, Van Der Valk, P, Jansen, R W, Abbink, F, Bosscha, M, Castelijns, J A, Moll, A C & de Graaf, P 2020, ' Full-width postlaminar optic nerve tumor invasion of retinoblastoma as risk-factor for leptomeningeal spread of retinoblastoma. A case report and review of the literature ', Ophthalmic Genetics, vol. 41, no. 1, pp. 69-72 . https://doi.org/10.1080/13816810.2020.1727535 Ophthalmic Genetics, 41(1), 69-72. Taylor and Francis Ltd. |
| ISSN: | 1381-6810 |
| Popis: | We present a 6-year-old boy with unilateral retinoblastoma of the left eye. MRI showed an intraocular tumor that extended into the optic nerve beyond the lamina cribrosa. The affected eye was enucleated and the optic nerve resection margin proved to be free. Following protocol, this patient received six courses of adjuvant systemic chemotherapy. Unfortunately, after 5 months this patient returned with the leptomeningeal spread of the tumor and died quickly thereafter.Histopathologic analysis of the enucleated eye and distal optic nerve revealed that the postlaminar tumor cells occupied the entire width of the optic nerve, extending all the way up to the pia mater, whereas, more often the tumor invasion is restricted to the center of the optic nerve. This was also visible on the MR images where contrast enhancement occupied the entire nerve width. A resection margin with tumor cells is recognized as a risk factor for metastasis, but perhaps the proximity of tumor cells to the leptomeninges should also be judged with caution as a potential increased risk for metastatic spread. |
| Databáze: | OpenAIRE |
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