An autopsy case of corticobasal syndrome with pure diffuse Lewy Body Disease
| Autor: | Mutsufusa Watanabe, Keiko Ichinose, Hiroto Fujigasaki, Toshiki Uchihara, Saneyuki Mizutani, Toru Tanizawa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Lewy Body Disease
Male Pathology medicine.medical_specialty Autopsy 050105 experimental psychology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Arts and Humanities (miscellaneous) Parkinsonian Disorders mental disorders medicine Humans 0501 psychology and cognitive sciences Pathological Retrospective Studies Alpha-synuclein business.industry Parkinsonism 05 social sciences Middle Aged medicine.disease chemistry Frontal lobe Neurology (clinical) Tauopathy Lewy body disease business 030217 neurology & neurosurgery Frontotemporal dementia |
| Zdroj: | Neurocase. 27(3) |
| ISSN: | 1465-3656 |
| Popis: | Corticobasal syndrome (CBS) is associated with diverse pathological substrates such as tau, prion protein, transactive response and, rarely, alpha synuclein. We report the case of a54-year-old man, who presented with asymmetric levodopa-poor-responsive parkinsonism, frontal lobe signs and behavioral changes. He was diagnosed with CBS, and postmortem analyses revealed Lewy body disease Braak stage VI without comorbid pathologies. Retrospectively, the clinical course of our patient and previous reports indicate that CBS plus mood changes and autonomic dysfunction, including reduced uptake of metaiodobenzylguanidine, are predictive factors of Lewy body pathology, even if the clinical picture is atypical. |
| Databáze: | OpenAIRE |
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