DNA repair capacity and response to treatment of colon cancer
| Autor: | Tomas Buchler, Ludmila Vodickova, Pavel Vodicka, Sona Vodenkova |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Genome instability DNA Repair DNA repair Colorectal cancer Biology Malignancy Genome Genomic Instability Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Genetics medicine Humans Gene Pharmacology Cell Death Cancer Prognosis medicine.disease Gene Expression Regulation Neoplastic Biomarker 030104 developmental biology 030220 oncology & carcinogenesis Colonic Neoplasms Mutation Cancer research Molecular Medicine DNA Damage |
| Zdroj: | Pharmacogenomics. 20:1225-1233 |
| ISSN: | 1744-8042 1462-2416 |
| Popis: | DNA repair, a complex biological process, ensures genomic integrity. Alterations in DNA repair, occurring in many cancers, contribute to the accumulation of mutations in the genome, resulting in genomic instability and cancer progression. DNA repair also plays a substantial role in response to chemotherapeutics: rapidly dividing colon cancer cells, vulnerable to DNA-damaging agents and overcoming DNA repair, undergo cell death. DNA repair capacity represents a complex biomarker, integrating gene variants, gene expressions, the stability of gene products, the effect of inhibitors/stimulators, lifestyle and environmental factors. Here, we discuss DNA repair capacity in sporadic colon cancer, a frequent malignancy worldwide, in relation to tumor heterogeneity, prognosis and prediction, measurements in surrogate and target tissues and suggest important tasks to be addressed. |
| Databáze: | OpenAIRE |
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