Single photon emission computerized tomography (SPECT) in detecting neurodegeneration in Huntington's disease
| Autor: | Robert W. Prost, Ronald S. Tikofsky, Benezra Ee, Hamsher Ks, Lebel Rr, Sara J. Swanson, Leighton P. Mark, Elejalde Br, Robert S. Hellman, Norman C. Reynolds |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Neuropathology Central nervous system disease Degenerative disease Huntington's disease medicine Dementia Humans Radiology Nuclear Medicine and imaging Aged Dystonia Tomography Emission-Computed Single-Photon Clinical pathology business.industry Reverse Transcriptase Polymerase Chain Reaction Chorea General Medicine DNA Middle Aged medicine.disease Huntington Disease Nerve Degeneration Female medicine.symptom Radiopharmaceuticals business |
| Zdroj: | Nuclear medicine communications. 23(1) |
| ISSN: | 0143-3636 |
| Popis: | Single photon emission computerized tomography (SPECT) studies were performed on 34 manifest Huntington's disease (HD) patients at various stages of clinical pathology ranging from early chorea to late dystonia with or without signs of dementia and 12 pre-symptomatic patients with abnormal terminal CAG expansions. Thirty HD patients with obvious clinical signs and seven pre-symptomatic patients without signs or symptoms of HD displayed selective caudate hypoperfusion by direct visual inspection. Such qualitative, selective striatal hypoperfusion patterns can be indicative of early and persistent metabolic changes in striatal neuropathology. SPECT studies can be useful in documenting early pre-clinical changes in patients with abnormal terminal CAG expansions and in confirming the presence of caudate pathology in patients with clinical signs of HD. |
| Databáze: | OpenAIRE |
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