1,2-cyclic sulfamidates as versatile precursors to thiomorpholines and piperazines

Autor:	Diane Gray, Suda Chakthong, Ron M. Lawrence, Timothy Gallagher, Andrew Williams
Rok vydání:	2003
Předmět:	Nucleophile Chemistry Organic Chemistry Polymer chemistry Displacement (orthopedic surgery) General Medicine Physical and Theoretical Chemistry Biochemistry Combinatorial chemistry Methyl thioglycolate
Zdroj:	Organic letters. 5(6)
ISSN:	1523-7060
Popis:	[reaction: see text] 1,2-Cyclic sulfamidates undergo regiospecific nucleophilic displacement with either methyl thioglycolate or alpha-amino esters, followed by lactamization (thermal, base-mediated, or cyanide-catalyzed), to give thiomorpholin-3-ones and piperazin-2-ones.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5730e6a4e3ddd4790169bb2a92178f https://pubmed.ncbi.nlm.nih.gov/12633078 Zobrazit plný text záznamu