Rho-modifying bacterial protein toxins from Photorhabdus species
| Autor: | Klaus Aktories, Alexander E. Lang, Thomas Jank |
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| Rok vydání: | 2016 |
| Předmět: |
Models
Molecular rho GTP-Binding Proteins 0301 basic medicine Insecta animal structures Bacterial Toxins GTPase Toxicology Microbiology 03 medical and health sciences Protein Domains Heterotrimeric G protein Photorhabdus luminescens Animals Tyrosine Deamidation 030102 biochemistry & molecular biology biology biology.organism_classification 030104 developmental biology Biochemistry Larva ADP-ribosylation Photorhabdus Bacteria |
| Zdroj: | Toxicon. 116:17-22 |
| ISSN: | 0041-0101 |
| DOI: | 10.1016/j.toxicon.2015.05.017 |
| Popis: | Photorhabdus bacteria live in symbiosis with entomopathogenic nematodes. The nematodes invade insect larvae, where they release the bacteria, which then produce toxins to kill the insects. Recently, the molecular mechanisms of some toxins from Photorhabdus luminescens and asymbiotica have been elucidated, showing that GTP-binding proteins of the Rho family are targets. The tripartite Tc toxin PTC5 from P. luminescens activates Rho proteins by ADP-ribosylation of a glutamine residue, which is involved in GTP hydrolysis, while PaTox from Photorhabdus asymbiotica inhibits the activity of GTPases by N-acetyl-glucosaminylation at tyrosine residues and activates Rho proteins indirectly by deamidation of heterotrimeric G proteins. |
| Databáze: | OpenAIRE |
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