Prevaccination Glycan Markers of Response to an Influenza Vaccine Implicate the Complement Pathway

Autor:	Rui Qin, Guanmin Meng, Smruti Pushalkar, Michael A. Carlock, Ted M. Ross, Christine Vogel, Lara K. Mahal
Rok vydání:	2022
Předmět:	Glycosylation Influenza Vaccines Polysaccharides Influenza Human Humans Proteins General Chemistry Antibodies Viral Mannose Biochemistry
Zdroj:	Journal of Proteome Research. 21:1974-1985
ISSN:	1535-3907 1535-3893
Popis:	A key to improving vaccine design and vaccination strategy is to understand the mechanism behind the variation of vaccine response with host factors. Glycosylation, a critical modulator of immunity, has no clear role in determining vaccine responses. To gain insight into the association between glycosylation and vaccine-induced antibody levels, we profiled the pre- and postvaccination serum protein glycomes of 160 Caucasian adults receiving the FLUZONE influenza vaccine during the 2019-2020 influenza season using lectin microarray technology. We found that prevaccination levels of Lewis A antigen (Le
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5484620df4adeca854d9a71c9b2a41 https://doi.org/10.1021/acs.jproteome.2c00251 Zobrazit plný text záznamu