Prevaccination Glycan Markers of Response to an Influenza Vaccine Implicate the Complement Pathway
Autor: | Rui Qin, Guanmin Meng, Smruti Pushalkar, Michael A. Carlock, Ted M. Ross, Christine Vogel, Lara K. Mahal |
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Rok vydání: | 2022 |
Předmět: | |
Zdroj: | Journal of Proteome Research. 21:1974-1985 |
ISSN: | 1535-3907 1535-3893 |
Popis: | A key to improving vaccine design and vaccination strategy is to understand the mechanism behind the variation of vaccine response with host factors. Glycosylation, a critical modulator of immunity, has no clear role in determining vaccine responses. To gain insight into the association between glycosylation and vaccine-induced antibody levels, we profiled the pre- and postvaccination serum protein glycomes of 160 Caucasian adults receiving the FLUZONE influenza vaccine during the 2019-2020 influenza season using lectin microarray technology. We found that prevaccination levels of Lewis A antigen (Le |
Databáze: | OpenAIRE |
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