The relation between urinary angiotensinogen and proteinuria in renal AA amyloidosis patients

Autor:	Aysun Aybal Kutlugun, Mustafa Arici, Rahmi Yilmaz, Bulent Altun, Cetin Turgan, Yunus Erdem, Ercan Turkmen, Tolga Yildirim, Mahmut Altindal, Umit Aktan
Rok vydání:	2012
Předmět:	Adult Male medicine.medical_specialty Urinary system Angiotensinogen Urology chemistry.chemical_compound AA amyloidosis Internal medicine Renin–angiotensin system Internal Medicine medicine Humans In patient Serum Amyloid A Protein Creatinine Proteinuria business.industry Case-control study Amyloidosis Middle Aged medicine.disease Familial Mediterranean Fever Spot urine Endocrinology chemistry Case-Control Studies Regression Analysis Female Kidney Diseases medicine.symptom business Biomarkers
Zdroj:	Amyloid. 19:28-32
ISSN:	1744-2818 1350-6129
DOI:	10.3109/13506129.2012.654530
Popis:	The aim of this study was to evaluate the relationship of local intrarenal renin angiotensin system (RAS) with proteinuria in patients with renal AA amyloidosis.Thirty-two patients with renal AA amyloidosis (19 male, mean age: 45 ± 13 years) and sixteen healthy controls (5 male, mean age: 32 ± 5 years) were included in this study. Spot urine samples were obtained to measure urinary angiotensinogen (AGT) using human AGT-ELISA, urinary creatinine and protein levels. Logarithmic transformations of urinary AGT-creatinine ratio log(UAGT/Ucre) and urinary protein-to-creatinine ratio (UPCR) were done to obtain the normal distributions of these parameters.Log(UAGT/UCre) was significantly higher in patients compared with the controls (1.88 ± 0.92 µg/g vs. 1.25 ± 0.70 µg/g; p = 0.023). Importantly a significantly positive correlation was found between log(UAGT/Ucre) and logUPCR in patients (r = 0.595, p = 0.006).Urinary AGT levels are higher in renal AA amyloidosis patients than in controls. Also, there is a significant positive correlation between urinary AGT and proteinuria in renal AA amyloidosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d54298670d71eda894507ec1ede6ff2 https://doi.org/10.3109/13506129.2012.654530 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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