Biofunctionalized Zinc Oxide Field Effect Transistors for Selective Sensing of Riboflavin with Current Modulation
| Autor: | Nancy Kelley-Loughnane, Morley O. Stone, Joshua A. Hagen, Sang N. Kim, Kevin D. Leedy, Burhan Bayraktaroglu, Jorge L. Chávez, Rajesh R. Naik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Transistors
Electronic Metallocenes Aptamer Riboflavin chemistry.chemical_element DNA Single-Stranded Nanotechnology Zinc Biosensing Techniques lcsh:Chemical technology Biochemistry label-free Analytical Chemistry Riboflavin binding chemistry.chemical_compound sensor lcsh:TP1-1185 Ferrous Compounds Electrical and Electronic Engineering ZnO-FET Instrumentation Aqueous solution Chemistry Communication biofunctionalization selectivity Substrate (chemistry) aptamer Aptamers Nucleotide Combinatorial chemistry Small molecule Atomic and Molecular Physics and Optics Nanostructures Ferrocene Covalent bond biomolecular detection Zinc Oxide |
| Zdroj: | Sensors (Basel, Switzerland) Sensors, Vol 11, Iss 7, Pp 6645-6655 (2011) |
| ISSN: | 1424-8220 |
| Popis: | Zinc oxide field effect transistors (ZnO-FET), covalently functionalized with single stranded DNA aptamers, provide a highly selective platform for label-free small molecule sensing. The nanostructured surface morphology of ZnO provides high sensitivity and room temperature deposition allows for a wide array of substrate types. Herein we demonstrate the selective detection of riboflavin down to the pM level in aqueous solution using the negative electrical current response of the ZnO-FET by covalently attaching a riboflavin binding aptamer to the surface. The response of the biofunctionalized ZnO-FET was tuned by attaching a redox tag (ferrocene) to the 3’ terminus of the aptamer, resulting in positive current modulation upon exposure to riboflavin down to pM levels. |
| Databáze: | OpenAIRE |
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