Simultaneous Measurement of In Vitro Gastroduodenal Prostaglandin E2Synthesis and Degradation in Peptic Ulcer Disease
| Autor: | W. D. W. Rees, J. R. Crampton, Linda Gibbons |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Duodenum Prostaglandin Disease In Vitro Techniques digestive system Gastroenterology Dinoprostone chemistry.chemical_compound Internal medicine medicine Humans Stomach Ulcer Intestinal Mucosa Prostaglandin E2 Antrum Aged business.industry Prostaglandins E Stomach digestive oral and skin physiology Middle Aged digestive system diseases In vitro medicine.anatomical_structure chemistry Gastric Mucosa Duodenal Ulcer Gastritis Female lipids (amino acids peptides and proteins) medicine.symptom business medicine.drug |
| Zdroj: | Scandinavian Journal of Gastroenterology. 22:425-430 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365528708991485 |
| Popis: | The ability of mucosal specimens from the stomach and duodenum to synthesize and degrade prostaglandin E2 has been determined in normal subjects and peptic ulcer patients. Significant reduction in fundic PGE2 synthesis capacity was observed in gastric ulcer patients. There was also significant reduction in the PGE2 degradation capacity of antral, fundic, and duodenal mucosal specimens in gastric ulcer patients. Patients with gastritis showed significant elevation of both antral and fundic PGE2 synthesis capacity compared with normal but no alteration in PGE2 degradation. No differences were observed in PGE2 synthesis and degradation rates in patients with duodenal ulcer. The results argue in favour of an association between impairment of PGE2 metabolism in the mucosa of patients with gastric but not duodenal ulceration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|