HPV genotyping and risk factors for anal high-risk HPV infection in men who have sex with men from Toronto, Canada
| Autor: | Robert S. Remis, Rupert Kaul, Sanja Huibner, Yoojin Choi, Roberta Halpenny, Anuradha Rebbapragada, Juan Liu, Troy Grennan, Mona Loutfy, Jason Brunetta, Graham C. Smith, Tatjana Reko |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Canada Hpv genotyping Genotype Science Anal Canal Diseases Alphapapillomavirus Logistic regression Article Men who have sex with men Continuous variable 03 medical and health sciences 0302 clinical medicine Medicine Anal cancer Humans 030212 general & internal medicine Multivariable model Homosexuality Male Anus Diseases Multidisciplinary business.industry Papillomavirus Infections virus diseases Middle Aged medicine.disease 3. Good health 030104 developmental biology Sexual Partners Risk factors High risk hpv business Demography |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Men who have sex with men (MSM) are disproportionately affected by anal cancer, predominantly caused by high-risk (HR) human papillomavirus (HPV) infection. Currently, the nonavalent HPV vaccine provides coverage against nine HPV genotypes, including seven HR-HPV genotypes. Here, we characterize anal HR-HPV genotype distribution and associated risk factors in MSM from Toronto, Canada recruited between September 2010 and June 2012. Wilcoxon–Mann–Whitney test was used for continuous variables, Chi-square test was performed for categorical variables, and a multivariable model using logistic regression was created to assess for correlates of anal HR-HPV infection. A total of 442 MSM were recruited, with a median age of 45 (IQR 38–50) and an overall HPV prevalence of 82%. The prevalence of any HR-HPV infection was 65.3% and 50.7% in the HIV-positive and HIV-negative MSM, respectively. No participant tested positive for all genotypes covered by the nonavalent vaccine. HIV status (aOR 1.806; 95% CI 1.159–2.816), smoking (aOR 2.176; 95% CI 1.285–3.685) and the number of lifetime sexual partners (aOR 2.466; 95% CI 1.092–5.567) were independent risk factors for anal HR-HPV infection. Our findings will be useful to inform HPV vaccine rollout and HPV prevention strategies in Canadian MSM. |
| Databáze: | OpenAIRE |
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