Modulation of Antimicrobial Peptide Potency in Stressed Lipid Bilayers
| Autor: | Valeria Losasso, Ya-Wen Hsiao, Jason Crain, Fausto Martelli, Martyn Winn |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Chemistry Lipid Bilayers Antimicrobial peptides General Physics and Astronomy Peptide Antimicrobial 01 natural sciences Molecular dynamics Membrane Models Chemical Tensile Strength 0103 physical sciences Phosphatidylcholines Biophysics Potency Computer Simulation 010306 general physics Chemical property Lipid bilayer Antimicrobial Cationic Peptides |
| Zdroj: | Physical Review Letters. 122 |
| ISSN: | 1079-7114 0031-9007 |
| Popis: | It is shown that the tendency of an archetypal antimicrobial peptide to insert into and perforate a simple lipid bilayer is strongly modulated by tensile stress in the membrane. The results, obtained through molecular dynamics simulations, have been demonstrated with several lipid compositions and appear to be general, although quantitative details differ. The findings imply that the potency of antimicrobial peptides may not be a purely intrinsic chemical property and, instead, depends on the mechanical state of the target membrane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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