Effects of vascular risk factors, statins, and antihypertensive drugs on PiB deposition in cognitively normal subjects
| Autor: | Anup Deshpande, Yi Li, Schantel Williams, Angela R. Kamer, Lisa Mosconi, Ricardo S. Osorio, Lidia Glodzik, John D. Murray, Wai Tsui, Pauline McHugh, Elizabeth Pirraglia, Shankar Vallabhajolusa, Tracy Butler, Catherine Randall, Henry Rusinek, Mony J. de Leon |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Amyloid Vascular risk Pharmacology Healthy elderly 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders medicine Dementia Diuretics Diagnostic Assessment & Prognosis Statins angiotensin receptor blockers business.industry Brain PET-PiB medicine.disease Obesity 3. Good health Psychiatry and Mental health 030104 developmental biology Amyloid deposition Vascular risk factors Neurology (clinical) business Antihypertensive medications 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring |
| ISSN: | 2352-8729 |
| Popis: | IntroductionHypertension, hypercholesterolemia, and obesity increase the risk of dementia. Although their detection is commonly followed by an introduction of treatment, little is known about how medications frequently used to treat vascular risk affect amyloid deposition.MethodsA cross-sectional study of 156 subjects who underwent positron emission tomography with PiB. Using linear regression, we tested whether blood pressure, cholesterol, overweight/obese status, angiotensin receptor blockers (ARBs), beta-blockers, diuretics, angiotensin converting enzyme inhibitors, and statins predicted amyloid deposition.ResultsThe use of ARBs (β = −.15, P = .044) and diuretics (β = −.20, P = .006) predicted less amyloid accumulation; older age (β = .29, P |
| Databáze: | OpenAIRE |
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