Evaluation of Mannose-Binding Lectin is a Useful Approach to Predict the Risk of Infectious Complications Following Autologous Hematopoietic Stem Cell Transplantation
| Autor: | Árpád Illés, Ildikó Pál, Mária Papp, Zita Radnay, Jolan Harsfalvi, Attila Kiss, L. Rejto, Miklós Udvardy |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.drug_class medicine.medical_treatment Antibiotics chemical and pharmacologic phenomena Enzyme-Linked Immunosorbent Assay Hematopoietic stem cell transplantation 030230 surgery Klinikai orvostudományok Mannose-Binding Lectin 03 medical and health sciences 0302 clinical medicine Postoperative Complications Antigen Risk Factors medicine Humans Mannan-binding lectin Transplantation biology Acute-phase protein Hematopoietic Stem Cell Transplantation Orvostudományok Middle Aged bacterial infections and mycoses MBL deficiency medicine.disease C-Reactive Protein Immunology biology.protein 030211 gastroenterology & hepatology Surgery Female Antibody Biomarkers Metabolism Inborn Errors |
| Popis: | Hematopoietic stem cell transplantation (HSCT) associated immunocompromised state carries high risk of infectious complications. Mannose-binding lectin (MBL) is an acute phase protein involved in innate immune response. Serum MBL level is genetically determined and quite stable. According to literature, significant association was shown between low MBL concentrations and serious infections. The association between serum MBL level and frequency and severity of infections was studied in 186 patients following autologous HSCT. Double-monoclonal antibody sandwich enzyme-linked immunosorbent assay was used to determine MBL antigen level in sera. MBL levels were measured around 100 days following transplantation, in a period without active infection. Twenty-one patients (11%) were MBL deficient. The median time of first infection and number of infections during the first year post-transplantation were not significantly different between patients with MBL deficiency and those without MBL deficiency. The occurrence and number of infections after HSCT correlated with the MBL/C-reactive protein ratio. The number of severe infections was not higher among those with MBL deficiency. The occurrence of infections after the pre-engraftment period during the first year post-transplantation was significantly different in patient groups separated by MBL cut-off level. The MBL/C-reactive protein ratio might be a useful marker of infectious complications. MBL measurement may be helpful in antibiotic treatment. In case of MBL deficiency, earlier and more intensive treatment may be indicated. |
| Databáze: | OpenAIRE |
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