Implantation of a modified stented bovine pulmonary valve in a beating heart sheep model
| Autor: | Yongshan Zhang, Fei Teng, Juan Xiao, Guowei Meng, Weiguo Bao, Qingling Zhou, Qiang Sun |
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| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Time Factors Radiography medicine.medical_treatment Hemodynamics Regurgitation (circulation) 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals cardiovascular diseases Thrombus Heart Valve Prosthesis Implantation Pulmonary Valve Sheep business.industry Angiography Stent equipment and supplies medicine.disease Heart Valves Surgery Stenosis medicine.anatomical_structure 030228 respiratory system Echocardiography Pulmonary valve Models Animal Cardiology Cattle Stents Cardiology and Cardiovascular Medicine business Calcification Follow-Up Studies |
| Zdroj: | Journal of cardiac surgery. 32(8) |
| ISSN: | 1540-8191 |
| Popis: | Purpose The aim of this research was to assess the performance of a modified bovine stent valve implanted transventricularly in the pulmonary position in sheep with a 3-month follow-up period. Materials and Methods Seven modified pulmonary bovine stent valves were transventricularly implanted in the pulmonary position into seven sheep using a delivery system. Stent valve performance was investigated and evaluated hemodynamically, angiographically, and with echocardiograms before, immediately after, and 3 months following implantation. Macroscopic, histologic, and radiographic examinations were performed on the explanted graft at 3 months. Results The modified stent valves were all deployed and implanted successfully in the pulmonary position in seven sheep. Angiographic, echocardiographic, hemodynamic, and macroscopic analyses confirmed firm anchoring of the stents in the target position in the early and 3-month follow-up period. All modified stent valves showed satisfactory function, except one moderate stenosis (32 mmHg gradient) with mild regurgitation that was discovered at 3 months. All seven valves were free of any calcification and thrombus formation at postmortem macroscopic examination, which was confirmed by histologic and radiographic examination. All stents were intact without any fracture at microscopic or radiographic examination. Conclusions Transventricular implantation of a modified nitinol pulmonary valve stent showed good structural and functional outcomes without stent fracture or migration. |
| Databáze: | OpenAIRE |
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