Critical role of endogenousMtv in acute lethal graft-versus-host disease
| Autor: | Thierry Roger, Martine Bruley-Rosset, Isabelle Miconnet, Michel Seman |
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| Rok vydání: | 1995 |
| Předmět: |
Receptors
Antigen T-Cell alpha-beta T-Lymphocytes T cell Immunology Graft vs Host Disease Mice Inbred Strains chemical and pharmacologic phenomena Endogeny Biology Mice Proviruses parasitic diseases medicine Superantigen Minor histocompatibility antigen Animals Immunology and Allergy Superantigens T-cell receptor Mouse mammary tumor virus medicine.disease biology.organism_classification Transplantation surgical procedures operative Graft-versus-host disease medicine.anatomical_structure Mammary Tumor Virus Mouse Acute Disease |
| Zdroj: | European Journal of Immunology. 25:364-368 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.1830250209 |
| Popis: | Little is known about the etiology of the graft-versus-host disease (GVHD) occuring after transplantation of lymphoid cells incompatible for minor histocompatibility antigens (mHAg). Here, the potential role of host endogenous mouse mammary tumor virus (Mtv)-encoded superantigens (SAg) in the development of lethal GVHD was investigated. In a combination of H-2d compatible mice, the presence of Mtv-7 and, to a lesser extent, of Mtv-1, -6, -13 in the host genome, highly increases the rate and severity of GVHD. Kinetic analyses of TCR V beta gene expression in recipient mice consistently indicate a dramatic but transient infiltration of GVHD target organs by Mtv-SAg-specific T cells. This suggests that SAg encoded by endogenous Mtv, by activating large T cell subpopulations, would help the response to mHAg and thus play a critical role in the initiation or aggravation of GVHD. |
| Databáze: | OpenAIRE |
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