Simple prognostic markers for optimal treatment of patients with unresectable pancreatic cancer
| Autor: | Hideki Miyata, Yoichi Hiasa, Tomoyuki Yokota, Naozumi Shibata, Yoshiki Imamura, Teruki Miyake, Ichinosuke Hyodo, Taira Kuroda, Teru Kumagi, Mitsuhito Koizumi, Yoshinori Ohno, Kozue Kanemitsu, Nobuaki Azemoto, Takashi Terao, Yoshinori Tanaka |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Palliative care CA-19-9 Antigen Neutrophils pancreatic cancer Observational Study Gastroenterology NLR Metastasis Pancreatic cancer Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Lymphocytes Neoplasm Metastasis prognostic factor Survival analysis Aged Proportional Hazards Models Retrospective Studies Aged 80 and over Proportional hazards model business.industry Palliative Care Hazard ratio palliative treatment General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Gemcitabine CAR Pancreatic Neoplasms Regimen Female business Research Article medicine.drug |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| DOI: | 10.1097/md.0000000000027591 |
| Popis: | Most patients with pancreatic cancer are ineligible for curative resection at diagnosis, resulting in poor prognosis. This study aimed to evaluate the prognostic factors in patients with unresectable pancreatic cancer. We retrospectively collected clinical data from 196 patients with unresectable pancreatic cancer who received palliative chemotherapy (N = 153) or palliative care alone (N = 43) from January 2011 to December 2013. Patients’ background data and overall survival were analyzed using the Cox proportional hazard regression model. In patients receiving palliative chemotherapy (gemcitabine-based regimen, 88.2%) and palliative care alone, the median (range) ages were 68 (43–91) and 78 (53–90) years, and metastatic diseases were present in 80% (N = 123) and 86% (N = 37), respectively. Multivariate analysis in the palliative chemotherapy patients showed that liver metastasis (hazard ratio [HR] 2.25, 95% confidence interval [CI] 1.58–3.20, P 4.5 vs ≤4.5; HR 3.45, 95% CI 2.22–5.36, P |
| Databáze: | OpenAIRE |
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