Use of Iodine-123 as a Diagnostic Tracer for Neck and Whole-Body Scanning in Patients with Well-Differentiated Thyroid Cancer
| Autor: | Halil Turgut Turoglu, Sleiman Naddaf, Jean Barsa, Hussein M. Abdel-Dayem, Iven S. Young, M. F. Akisik, Recaredo Berbano, Elsa Echemendia |
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| Rok vydání: | 1998 |
| Předmět: |
Whole Body Scanning
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism medicine.medical_treatment Well-Differentiated Thyroid Cancer Thyroid Thyroidectomy General Medicine medicine.disease Thyroid carcinoma Endocrinology medicine.anatomical_structure Iodine-123 Medicine In patient Radiology business Nuclear medicine Thyroid cancer |
| Zdroj: | Endocrine Practice. 4:11-16 |
| ISSN: | 1530-891X |
| Popis: | Objective To determine whether 123I can be used as a safe and effective alternative tracer to 131I for imaging remnant tissue and for searching for metastatic lesions of well-differentiated thyroid cancer. Methods We studied a series of 16 patients (10 women and 6 men; 29 to 73 years of age) who had well-differentiated thyroid cancer and had undergone thyroidectomy and subsequent radioiodine treatment. Diagnostic 123I scans at 4, 24, and 48 hours after oral administration of 10 mCi (either preablation or postablation) were compared with the 5- to 7-day 131I posttherapy scans (doses, 75 to 200 mCi). Scans were jointly interpreted by nuclear medicine and endocrinology staff members. Results Of the 16 patients, 15 had concordant findings between the 123I diagnostic images and the corresponding 131I posttherapy scans. Only one patient had additional lesions noted on the posttherapy 131I scan, which was attributed to the higher dose the patient received during radioiodine treatment (a 6% discordance rate). This discordance, however, would not have changed the patient treatment. No advantage was noted for delayed imaging at 48 hours; the 24-hour images were satisfactory. The 123I scans were of higher resolution than the 131I scans. Conclusion Diagnostic 123I scans are an acceptable alternative to 131I scanning for whole-body imaging in well-differentiated thyroid cancer and demonstrate adequate imaging of thyroid remnant tissue or metastatic lesions from thyroid carcinoma comparable to the post-therapy scans. 123I scans also offer greater convenience to patients because they do not have to return for 48- or 72-hour scans. Furthermore, they facilitate earlier institution of therapy by decreasing the interval between diagnostic scanning and radioiodine treatment. (Endocr Pract. 1998; 4:11-16) |
| Databáze: | OpenAIRE |
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