An assessment of the onset and duration of action of olopatadine nasal spray
| Autor: | Piyush, Patel, Peter S, Roland, Bradley F, Marple, Paul J, Benninger, Harriet, Margalias, Michael, Brubaker, Sally F, Beezley, Susan F, Beezley, Margaret, Drake, Susan L, Potts, G Michael, Wall |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Time Factors Adolescent medicine.medical_treatment Treatment outcome Placebos 03 medical and health sciences 0302 clinical medicine Double-Blind Method Anti-Allergic Agents Medicine Humans 030223 otorhinolaryngology Olopatadine Hydrochloride Administration Intranasal Aged Aerosols business.industry Rhinitis Allergic Seasonal Environmental exposure Environmental Exposure Olopatadine Allergens Middle Aged Environment Controlled Treatment Outcome Otorhinolaryngology Nasal spray Patient Satisfaction 030220 oncology & carcinogenesis Anesthesia Pollen Surgery Nasal administration Female Ambrosia Safety business Dibenzoxepins medicine.drug |
| Zdroj: | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. 137(6) |
| ISSN: | 0194-5998 |
| Popis: | Seasonal allergic rhinitis (SAR) is a highly prevalent disease. This study was conducted to evaluate the onset and duration of action of three concentrations of olopatadine nasal spray.This was a randomized, double-blind, single-dose, placebo-controlled study, conducted in an environmental exposure chamber in patients with SAR. A total of 320 patients were exposed to ragweed allergen in the chamber and randomized to olopatadine nasal spray 0.2%, 0.4%, 0.6%, or placebo nasal spray. Symptoms (sneezing, runny, itchy, and stuffy nose) were self-assessed during a 12-hour study period.All concentrations of olopatadine nasal spray provided clinically meaningful reductions in total nasal symptom scores at 30 minutes compared to the placebo. Olopatadine nasal spray 0.6% was significantly more effective (P0.05) than placebo nasal spray at all time-points starting at 90 minutes post-dose and continuing over 12 hours.Olopatadine nasal spray 0.6% demonstrated a fast onset of action and maintained an effect for at least 12 hours after dosing. |
| Databáze: | OpenAIRE |
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