Adult neurogenesis beyond the niche: its potential for driving brain plasticity
| Autor: | Pierre-Marie Lledo, Alejandro F. Schinder, Kurt A. Sailor |
|---|---|
| Přispěvatelé: | Perception et Mémoire / Perception and Memory, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Laboratory of Neuronal Plasticity [Buenos Aires], Instituto de Investigaciones Bioquímicas [Buenos Aires] (IIBBA), Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)- Fundación Instituto Leloir [Buenos Aires]-Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET)- Fundación Instituto Leloir [Buenos Aires], The Lledo lab was supported by the life insurance company ‘AG2R-La-Mondiale’, Agence Nationale de la Recherche (ANR-15-CE37-0004-01 and ANR-15-NEUC-0004 (Circuit-OPL)), and the Laboratory for Excellence Programme ‘Revive’ (Investissement d’Avenir, ANR-10-LABX-73) with a fellowship from ‘Revive’ (KAS). The Schinder lab was supported by the Argentine Agency for the Promotion of Science and Technology (PICT2013-1685) and the Howard Hughes Medical Institute (SIRS grant #55007652). AFS was supported by the Argentine Research Council (CONICET)., ANR-15-NEUC-0004,CIRCUIT-OPL,US-French Research Proposal- Neural Circuits and Plasticity- Olfactory Perception and Learning(2015), ANR-15-CE37-0004,SmellBrain,Dissection fonctionnelle des circuits codant pour la récompense dans le système olfactif(2015), ANR-10-LABX-0073,REVIVE,Stem Cells in Regenerative Biology and Medicine(2010), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Neurogenesis Niche Plasticity Biology Ciencias Biológicas 03 medical and health sciences 0302 clinical medicine Neuroplasticity medicine Sensory deprivation Neurons Neuronal Plasticity General Neuroscience [SCCO.NEUR]Cognitive science/Neuroscience Brain Bioquímica y Biología Molecular neurogenesis 030104 developmental biology medicine.anatomical_structure Synaptic plasticity Synapses Neuron Neuroscience CIENCIAS NATURALES Y EXACTAS 030217 neurology & neurosurgery |
| Zdroj: | Current Opinion in Neurobiology Current Opinion in Neurobiology, 2017, 42, pp.111-117. ⟨10.1016/j.conb.2016.12.001⟩ Current Opinion in Neurobiology, Elsevier, 2017, 42, pp.111-117. ⟨10.1016/j.conb.2016.12.001⟩ |
| ISSN: | 0959-4388 |
| Popis: | Adult neurogenesis emerges as a tremendous form of plasticity with the continuous addition and loss of neurons in the adult brain. It is unclear how preexisting adult circuits generated during development are capable of modifying existing connections to accommodate the thousands of new synapses formed and exchanged each day. Here we first make parallels with sensory deprivation studies and its ability to induce preexisting non-neurogenic adult circuits to undergo massive reorganization. We then review recent studies that show high structural and synaptic plasticity in circuits directly connected to adult-born neurons. Finally, we propose future directions in the field to decipher how host circuits can accommodate new neuron integration and to determine the impact of adult neurogenesis on global brain plasticity. Fil: Sailor, Kurt A.. Centre National de la Recherche Scientifique; Francia. Instituto Pasteur; Francia Fil: Schinder, Alejandro Fabián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: Lledo, Pierre-Marie. Centre National de la Recherche Scientifique; Francia. Instituto Pasteur; Francia |
| Databáze: | OpenAIRE |
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