Effects of acute metabolic stress on the dopaminergic and pituitary–adrenal axis activity in patients with schizophrenia, their unaffected siblings and controls
| Autor: | Jim van Os, Mohamed Saoud, Thierry d'Amato, Alain Cochet, Marie-Françoise Suaud-Chagny, Jerome Brunelin |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System medicine.medical_specialty Psychosis Hydrocortisone Exacerbation Dopamine Pituitary-Adrenal System Adrenocorticotropic hormone Deoxyglucose Placebos Adrenocorticotropic Hormone Double-Blind Method Risk Factors Stress Physiological Internal medicine medicine Humans Genetic Predisposition to Disease Biological Psychiatry Cross-Over Studies Siblings Stressor Dopaminergic Homovanillic Acid medicine.disease Control Groups Crossover study Psychiatry and Mental health Endocrinology Schizophrenia Female Psychology medicine.drug |
| Zdroj: | Schizophrenia Research. 100:206-211 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2007.11.009 |
| Popis: | A genetically mediated abnormal sensitivity to stress is thought to play a role in the onset, exacerbation and relapse of schizophrenia. In a double blind, placebo-controlled crossover study, peak increases in plasma ACTH (ΔACTH) and homovanillic-acid, a dopamine metabolite, (ΔHVA) following exposure to a metabolic stressor(2DG) were studied in unaffected siblings of patients with schizophrenia ( n = 15), their patient relatives ( n = 15) and healthy controls ( n = 14). Siblings showed a stress response (both ΔACTH and ΔHVA) that was significantly greater compared to controls and significantly less pronounced compared to patients. The results suggest that the genetic risk for schizophrenia may be characterized by an enhanced sensitivity to stress. |
| Databáze: | OpenAIRE |
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