Effects of Different Drying Methods on the Characterization, Dissolution Rate and Antioxidant Activity of Ursolic Acid-Loaded Chitosan Nanoparticles
Autor: | Liu Panpan, Junliang Chen, Lujie Zhao, Xu Duan, Xing Ren, Weiwei Cao, Guangyue Ren |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
dissolution study
Health (social science) Aqueous solution Chemistry Ursolic acid Chemical technology chitosan nanoparticles Nanoparticle Plant Science TP1-1185 Health Professions (miscellaneous) Microbiology Article Freeze-drying Differential scanning calorimetry Spray drying microwave freeze drying Particle size Fourier transform infrared spectroscopy Dissolution Food Science Nuclear chemistry |
Zdroj: | Foods Volume 10 Issue 10 Foods, Vol 10, Iss 2470, p 2470 (2021) |
ISSN: | 2304-8158 |
DOI: | 10.3390/foods10102470 |
Popis: | To improve the water solubility of ursolic acid (UA), UA-loaded chitosan nanoparticles were firstly prepared by the ionotropic gelation method and dried by freeze drying (FD), microwave freeze drying (MFD) and spray drying (SD). The characterization of UA-loaded chitosan nanoparticles was performed with particle size, drug loading (DL), scanning electron microscope (SEM), fourier transform infrared spectroscopy (FT-IR), differential scanning calorimetry (DSC), dissolution studies and antioxidant activity. The results demonstrated that UA was successfully encapsulated into chitosan nanoparticles using sodium tripolyphosphate (TPP) as a cross-linker, with a 79% encapsulation efficiency. The spray-dried, UA-loaded chitosan nanoparticles had the lowest drug loading (11.8%) and the highest particle size (496.9 ± 11.20 nm). The particle size of UA-loaded chitosan nanoparticles dried by MFD and FD was lower, at 240.8 ± 12.10 nm and 184.4 ± 10.62 nm, respectively, and their antioxidant activity was higher than those nanoparticles dried by SD. Moreover, the drying time and energy consumption of UA-loaded chitosan nanoparticles dried by MFD and SD were lower than that of FD. The dissolution rates of UA-loaded chitosan nanoparticles prepared by FD and MFD were 60.6% and 57.1%, respectively, in a simulated gastric fluid, which was a greater value than SD (55.9%). Therefore, the UA-loaded chitosan nanoparticles encapsulation method, combined with MFD technology, showed a promising potential to improve the water solubility of UA. |
Databáze: | OpenAIRE |
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