AdipoScan: A Novel Transient Elastography-Based Tool Used to Non-Invasively Assess Subcutaneous Adipose Tissue Shear Wave Speed in Obesity
| Autor: | Jean-Luc Bouillot, Michel Clet, Véronique Miette, Yuejun Liu, Meriem Abdennour, Pierre Bedossa, Joan Tordjman, Laurent Sandrin, Magali Sasso, Judith Aron-Wisnewsky, Gilles Le Naour, Karine Clément |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Pathology Acoustics and Ultrasonics Abdominal Fat Subcutaneous Fat Biophysics 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Obesity Glycemic Radiological and Ultrasound Technology Phantoms Imaging business.industry Reproducibility of Results Wave speed Middle Aged medicine.disease 030104 developmental biology Cardiology Elasticity Imaging Techniques Female Subcutaneous adipose tissue Liver dysfunction business Transient elastography Dyslipidemia |
| Zdroj: | Ultrasound in Medicine & Biology. 42:2401-2413 |
| ISSN: | 0301-5629 |
| Popis: | We describe a novel device called the AdipoScan that was adapted from the FibroScan to specifically assess shear wave speed (SWS) in human abdominal subcutaneous adipose tissue (scAT). Measurement reproducibility was assessed on tissue-mimicking phantoms with and without repositioning, with resultant coefficients of variation of 1% and 0%, respectively, as well as in vivo (14% and 7%, respectively). The applicability of the AdipoScan was tested on 19 non-obese volunteers, and a scAT thickness >2 cm was found to be mandatory to perform a valid measurement. Abdominal scAT SWS was assessed in 73 severely obese subjects, all candidates for bariatric surgery. Subcutaneous AT SWS was positively associated with scAT fibrosis and obesity-related co-morbidities such as hypertension, glycemic status, dyslipidemia and liver dysfunction. These results suggest that the AdipoScan could be a useful non-invasive tool to evaluate scAT fibrosis and metabolic complications in obesity. Further investigation is required to evaluate the relevance of using the AdipoScan to predict patient weight trajectories and metabolic outcomes after bariatric surgery. |
| Databáze: | OpenAIRE |
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